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KMID : 0882420020620040396
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Korean Journal of Medicine
2002 Volume.62 No. 4 p.396 ~ p.404
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Expression of p27Kip1 in gastric cancers and precancerous lesions
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Kim Nam-Il
Kang Hyeock-Joo
Jung Hee-Chul
Kim Sung-Jae
Lee Goo
Suh Jeong-Ill
Lee Chang-Woo
Lee Kyu-Chun
Kim Han-Sik
Jang Suk-Yong
Yang Chang-Heon
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Abstract
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Background: The cyclin-dependent kinase inhibitor p27Kip1 is a negative regulator of cell cycle progression at G1/S transition. Recently, the expression level of p27Kip1 was decreased in many cancers such as breast, pituitary gland, colon and stomach. We studied the exptression of p27Kip1 in gastric cancers, precancerous lesions and normal gastric tissues and analysed its correlation to clinicopathologic data including tumor differentiation, tumor depth, nodal and distant metastasis in gastric cancers.
Methods: p27Kip1 were immunohistochemically stained in the tissue specimens of 62 resected cancers, 110 corresponding adjacent non-neoplastic tissues, 22 gastric adenomas and 10 mormal gastric tissues. Adjacent non-neoplastic tissues consisted of 32 chronic gastritis, 29 intestinal metaplasia and 49 transitional mucosa.
Results: Gastric cancer showed significantly decerased expression level of p27Kip1 when
compared with non-neoplastic lesions and adenomas. Labeling index of p27Kip1 were more decreased in chronic gastritis, intestinal metaplasia and transitional mucosa than in normal mucosa. Early gatric cancers showed significantly decreased expression level of p27Kip1 when compared with advanced gastric cancers. In gastric, p27Kip1 laveling index was significantly decreased in diffuse type and presence of nodal metastasis however did not show relationship with distant metastasis and tumor depth of advanced gastric cancers.
Conclusion: We suggest that p27Kip1 may be decreased in the early stage of gastric carcinogenesis and play an important role in the progression and differentiation of gastric cancers. More further studies are thought to be necessary in order to evaluate its prognostic factor in gastric cancers.
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KEYWORD
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P27Kip1, Stomach meoplasm, Precancerous conditions
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